Selected Publications on Our Technology

Siddiqui T, Celikkaya H, Atasavum ZT, Popova S, Freudenberg U, Werner C, Kizil C. (2023) Three-Dimensional Biohybrid StarPEG-Heparin Hydrogel Cultures for Modeling Human Neuronal Development and Alzheimer's Disease Pathology. Methods in Molecular Biology. 2561:159-170. doi: 10.1007/978-1-0716-2655-9_8..

Freudenberg, U., Liang, Y., Kiick, K.L., and Werner, C. (2016). Glycosaminoglycan-Based Biohybrid Hydrogels: A Sweet and Smart Choice for Multifunctional Biomaterials. Advanced Materials 28, 8861-8891.

Celikkaya, H., Cosacak, M.I., Papadimitriou, C., Popova, S., Bhattarai, P., Biswas, S.N., Siddiqui, T., Wistorf, S., Nevado-Alcalde, I., Naumann, L., et al. (2019). GATA3 Promotes the Neural Progenitor State but Not Neurogenesis in 3D Traumatic Injury Model of Primary Human Cortical Astrocytes. Frontiers in Cellular Neuroscience 13, 23.

Papadimitriou, C., Celikkaya, H., Cosacak, M.I., Mashkaryan, V., Bray, L., Bhattarai, P., Brandt, K., Hollak, H., Chen, X., He, S., et al. (2018). 3D Culture Method for Alzheimer's Disease Modeling Reveals Interleukin-4 Rescues Abeta42-Induced Loss of Human Neural Stem Cell Plasticity. Developmental Cell 46, 85-101 e108.

Lohmann, N., Schirmer, L., Atallah, P., Wandel, E., Ferrer, R.A., Werner, C., Simon, J.C., Franz, S., and Freudenberg, U. (2017). Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice. Science Translational Medicine 9.

Schirmer L, Chwalek K, Tsurkan MV,  Freudenberg U, Werner C. (2020) Glycosaminoglycan-based hydrogels with  programmable host reactions. Biomaterials. 228:119557. 

Kühn S, Freyse J, Atallah P, Rademann J,  Freudenberg U, Werner C. Tuning the network charge of biohybrid hydrogel  matrices to modulate the release of SDF-1. (2021) Biol Chem. 402(11):1453-1464. 

Maitz, M.F., Freudenberg, U., Tsurkan, M.V., Fischer, M., Beyrich, T., and Werner, C. (2013). Bio-responsive polymer hydrogels homeostatically regulate blood coagulation. Nature Communications 4, 2168.

Freudenberg, U., Sommer, J.-U., Levental, K.R., Welzel, P.B., Zieris, A., Chwalek, K., Schneider, K., Prokoph, S., Prewitz, M., Dockhorn, R., et al. (2012a). Using Mean Field Theory to Guide Biofunctional Materials Design. Advanced Functional Materials 22, 1391-1398.

Freudenberg, U., Sommer, J.U., Levental, K.R., Welzel, P.B., Zieris, A., Chwalek, K., Schneider, K., Prokoph, S., Prewitz, M., Dockhorn, R., et al. (2012b). Using Mean Field Theory to Guide Biofunctional Materials Design. Advanced Functional Materials 22, 1391-1398.

Cosacak, M.I., Bhattarai, P., and Kizil, C. (2020). Alzheimer’s disease, neural stem cells and neurogenesis: cellular phase at single-cell level. Neural Regeneration Research 15, 824-827.

Schirmer, L., Atallah, P., Werner, C., and Freudenberg, U. (2016). StarPEG-Heparin Hydrogels to Protect and Sustainably Deliver IL-4. Advanced Healthcare Materials 5, 3157-3164.

Kizil, C., and Bhattarai, P. (2018). Is Alzheimer’s also a stem cell disease? – The zebrafish perspective. Frontiers in Cell and Developmental Biology 6, 159.

Tsurkan, M.V., Chwalek, K., Levental, K.R., Freudenberg, U., and Werner, C. (2011). Modular StarPEG-Heparin Gels with Bifunctional Peptide Linkers. Macromolecular Rapid Communications 31, 1529-1533.

Tsurkan, M.V., Chwalek, K., Prokoph, S., Zieris, A., Levental, K.R., Freudenberg, U., and Werner, C. (2013). Defined polymer-peptide conjugates to form cell-instructive starPEG-heparin matrices in situ. Advanced Materials 25, 2606-2610.

Tsurkan, M.V., Levental, K.R., Freudenberg, U., and Werner, C. (2010). Enzymatically degradable heparin-polyethylene glycol gels with controlled mechanical properties. Chemical Communications (Cambridge) 46, 1141-1143.

Zieris, A., Chwalek, K., Prokoph, S., Levental, K.R., Welzel, P.B., Freudenberg, U., and Werner, C. (2011). Dual independent delivery of pro-angiogenic growth factors from starPEG-heparin hydrogels. Journal of Controlled Release 156, 28-36.